The effects of hormone replacement therapy (HRT) wearing off depends on the type of hormones used and how long they have been taken. In general, the timeline for changes reversing after stopping HRT is: Estrogen - Effects like breast growth and fat redistribution can persist for 12-24 months or longer after stopping. Breast size may decrease somewhat but rarely goes back to pre-HRT levels. - Menopausal symptoms like hot flashes usually return within 1-3 months, though it can take 6 months or more. - Changes to genital tissues like thinning of the vaginal lining reverse within 3-12 months. Testosterone - Voice deepening and facial/body hair growth are irreversible. These will not change if testosterone is stopped after they have developed. - Muscle mass and fat distribution changes may take 6-12 months to reverse. - Menstrual cycles generally resume within 1-6 months of discontinuing. Fertility may take longer to return. Progesterone - Works synergistically with estrogen, so its effects like breast development and mood stabilization tend to persist until estrogen levels also drop. The duration HRT has been used also plays a role. The longer someone has been on cross-sex hormones, the longer some effects can continue even after stopping. Using HRT for years makes certain changes like breast growth very resilient. There is also a lot of individual variation in how rapidly hormonal changes reverse. Factors like genetics, lifestyle, age and dosage all play a role. Working closely with a doctor to taper dosages can help ease the transition off HRT.